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KMID : 0191120090240030461
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Journal of Korean Medical Science
2009 Volume.24 No. 3 p.461 ~ p.467
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Neuroblastoma Originating from Extra-abdominal Sites: Association with Favorable Clinical and Biological Features
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Sung Ki-Woong
Yoo Keon-Hee
Koo Hong-Hoe
Kim Ju-Youn
Cho Eun-Joo
Seo Yeon-Lim
Kim Jhin-Gook
Lee Suk-Koo
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Abstract
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Neuroblastomas originating from different sites might have different clinical and biological characteristics. In the present study, the clinical (age, sex and stage) and biological (N-myc amplification, Shimada pathology and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of patients with newly diagnosed neuroblastoma were compared according to the site of tumor origin (extra-abdominal versus abdominal). The event-free survival rate (EFS) was also compared between the two groups. Among 143 neuroblastomas, 115 tumors originated from the abdomen, 26 from extra-abdominal sites and 2 from unknown primary sites. Frequencies of stage 4 tumor and N-myc amplified tumor were lower in the extra-abdominal group than in the abdominal group (34.6% vs. 60.0%, P=0.019 and 4.2% vs. 45.0%, P<0.001, respectively). Levels of lactate dehydrogenase, ferritin and neuron-specific enolase were significantly lower in the extra-abdominal group than in the abdominal group. The probability of 5-yr EFS (+/-95% confidence interval) was higher in the extra-abdominal group than in the abdominal group (94.4+/-10.6% vs. 69.4+/-9.4%, P=0.026). Taken together, neuroblastomas originating from extra-abdominal sites might be associated with more favorable clinical and biological characteristics and a better outcome than neuroblastomas originating from abdomen.
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KEYWORD
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Neuroblastoma, Prognosis, Thorax, Transplantation, Autologous
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